Omega 3 fatty acids as a host modulator in chronic periodontitis patients: a randomised, double-blind, palcebo-controlled, clinical trial
Deore Girish D., Gurav Abhijit N., Patil Rahul, Shete Abhijeet R., NaikTari Ritam S., Inamdar Saurabh P.,
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( Deore Girish D. ) - Tatyasaheb Kore Dental College Department of Periodontology
( Gurav Abhijit N. ) - Tatyasaheb Kore Dental College Department of Periodontology
( Patil Rahul ) - Tatyasaheb Kore Dental College Department of Periodontology
( Shete Abhijeet R. ) - Tatyasaheb Kore Dental College Department of Periodontology
( NaikTari Ritam S. ) - Tatyasaheb Kore Dental College Department of Periodontology
( Inamdar Saurabh P. ) - Tatyasaheb Kore Dental College Department of Periodontology
KMID : 0363020140440010025
Abstract
Purpose: Periodontitis is an infectious disease caused predominantly by gram-negative anerobes. The host inflammatory response to these bacteria causes alveolar bone loss that is characterized as periodontitis. Omega-3 fatty acids (ω-3 FAs) have anti-inflammatory properties, thus have been used to treat some chronic inflammatory diseases such as cardiovascular disease and rheumatoid arthritis. We aimed to evaluate the effect of dietary supplementation with ω-3 FAs as a host modulating agent in patients with chronic periodontitis.
Methods: Sixty otherwise healthy subjects with moderate and severe chronic periodontitis were enrolled in our randomised, double-blind, placebo-controlled trial. The control group (CG, n=30) was treated with scaling and root planing (SRP) and given a placebo; the treatment group (TG, n=30) was treated with SRP and dietary supplementation of ω-3 FAs (one 300 mg tablet daily for 12 weeks). Periodontal clinical parameters and serum C-reactive protein (CRP) levels were evaluated in all patients at baseline, a 6-week and 12-week period after treatment.
Results: A significant reduction in the gingival index, sulcus bleeding index, pocket depth, and clinical attachment level was found in the TG compared to the CG at a 12-week period. However, no statistically significant changes in serum CRP levels were found.
Conclusions: Our findings suggest that ω-3 FAs can successfully reduce gingival inflammation, pocket depth, and attachment level gain. Dietary supplementation with ω-3 FAs may have potential benefits as a host modulatory agent in the prevention and/or adjunctive management of chronic periodontitis.
키워드
Chronic periodontitis ; C-reactive protein ; Omega-3 fatty acids
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